CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex compositionand telomere Length.
CRT0063465 (10, 100 nM, up to 84 days) blocks hypoglycemic telomere shortening in TCT116 cells[1].
CRT0063465 (10 nM, 1 week) modulates the composition of shelterin complexes in unstressed HCT116 cells[1].
CRT0063465 (100 nM, up to 100 h) has protective effect against Bleomycin -induced cytotoxicity in A2780 cells[1].
References:
[1]. Bilsland AE, et al. A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. Neoplasia. 2019;21(9):893-907.