Creatine phosphate is a phosphorylated form of creatine that is involved in energy storage in skeletal muscle and brain.1,2 It is formed from creatine by creatine kinase. Creatine phosphate (10 mM) reduces hydrogen peroxide- and ferrous ion-induced increases in malondialdehyde (MDA) levels in rat heart microsomes.3 It also prevents hydrogen peroxide-induced decreases in aortic flow, minute work, and peak aortic pressure in isolated perfused rat hearts when used at a concentration of 10 mM. Brain levels of creatine phosphate decrease following mild traumatic brain injury in rats.4
1.Wallimann, T., Wyss, M., Brdiczka, D., et al.Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasisBiochem. J.281(Pt 1)21-40(1992) 2.Wyss, M., and Kaddurah-Daouk, R.Creatine and creatinine metabolismPhysiol. Rev.80(3)1107-1213(2000) 3.Zucchi, R., Poddighe, R., Limbruno, U., et al.Protection of isolated rat heart from oxidative stress by exogenous creatine phosphateJ. Mol. Cell. Cardiol.21(1)67-73(1989) 4.Signoretti, S., Di Pietro, V., Vagnozzi, R., et al.Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the ratMol. Cell. Biochem.333(1-2)269-277(2010)