CRAMP (140-173) (mouse) (trifluoroacetate salt)

Cathelicidin-related antimicrobial peptide (CRAMP) (140-173) is a 34-amino acid peptide derivative of the 38-amino acid antimicrobial peptide CRAMP.^1,2 Mature CRAMP is formed from cleavage of the full-length peptide by cathepsin G.^3,4 CRAMP (140-173) (1 µg/ml) is active against K. pneumoniae in vitro.¹ It decreases neutrophil infiltration of colonic epithelial and luminal surfaces in a porcine model of colitis when administered at a dose of 10 mg/kg.⁵ Ileal administration of CRAMP (140-173) (10 mg/kg) decreases disease severity and cecal bacterial burden and increases survival in a mouse model of C. difficile infection.⁶ However, intra-articular administration of CRAMP (140-173) (10 µl of 25 µM) also increases disease severity and induces synovitis in a mouse model of surgery-induced osteoarthritis.⁷