Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM.1 It is a useful tool to study the impact of Gcn5-
1.Chimenti, F., Bizzarri, B., Maccioni, E., et al.A novel histone acetyltransferase inhibitor modulating Gcn5 network: Cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazoneJ. Med. Chem.52530-536(2009) 2.Ablack, J.N.G., Cohen, M., Thillainadesan, G., et al.Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivationJ. Virol.86(15)8198-8209(2012)