Corylin is a phenolic compound isolated from the Psoralea corylifolia L, with anti-inflammatory and immunosuppressive properties [1]. Corylin activates BAT and Beige adipocytes through SIRT1 and β3-AR regulation, exerting anti-obesity effect[2]. Corylin has been widely used to prolong the life span of aged mice under metabolic stress, improve physiological function, reduce metabolic stress and maintain tissue function[3].
In vitro, Corylin treatment for 24 hours significantly inhibited the proliferation of MCF-7 cells and MDA-MB-231 cells with IC50 values of 10.58µM and 13.59µM, respectively[4]. Treatment of RAW264.7 cells with 10µM Corylin for 24h inhibited cell viability and migration[5]. Pretreatment of BV2 cells with 10µM Corylin for 1 hour attenuated lipopolysaccharide (LPS) -induced inflammatory response, reduced TNF-α and IL-6 production, and inhibited MAPK phosphorylation[6].
In vivo, Corylin treatment via oral administration at a dose of 50mg/kg/day for 15 weeks reduced oxidative stress, VCAM-1 and NOX4 Expression, and atherosclerotic plaques in the thoracic aorta of cholesterol diet-treated mice[7]. Intraperitoneal injection of a single dose of Corylin (20mg/kg) for 12 hours significantly alleviated LPS-induced cardiac dysfunction and reduced inflammation in mice[8].
References:
[1] Qin Z, Li S, Yao Z, et al. Metabolic profiling of corylin in vivo and in vitro[J]. Journal of pharmaceutical and biomedical analysis, 2018, 155: 157-168.
[2] Chen C C, Kuo C H, Leu Y L, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation[J]. Pharmacological Research, 2021, 164: 105291.
[3] Wang T H, Tseng W C, Leu Y L, et al. The flavonoid corylin exhibits lifespan extension properties in mouse[J]. Nature communications, 2022, 13(1): 1238.
[4] Liu S, Wang L, Zhang R. Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target[J]. Libyan Journal of Medicine, 2021, 16(1): 1883224.
[5] Liu N, Yang Z, Yanzhang R, et al. Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway[J]. Scientific Reports, 2025, 15(1): 40724.
[6] Huang M Y, Tu C E, Wang S C, et al. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia[J]. BMC complementary and alternative medicine, 2018, 18(1): 221.
[7] Chen C C, Li H Y, Leu Y L, et al. Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice[J]. Antioxidants, 2020, 9(4): 275.
[8] Li C, Hou D, Huang Y, et al. Corylin alleviated sepsis-associated cardiac dysfunction via attenuating inflammation through downregulation of microRNA-214-5p[J]. Toxicology Research, 2024, 13(3): tfae081.
Corylin是从Psoralea corylifolia L中分离出的一种酚类化合物，具有抗炎和免疫抑制特性[1]。Corylin通过SIRT1和β3-AR调节激活棕色脂肪组织和米色脂肪细胞，发挥抗肥胖作用[2]。Corylin已被广泛用于延长代谢应激下老年小鼠的寿命、改善生理功能、减轻代谢应激并维持组织功能[3]。
在体外，Corylin处理24小时显著抑制了MCF-7细胞和MDA-MB-231细胞的增殖，IC50值分别为10.58µM和13.59µM[4]。使用10µM的Corylin处理RAW264.7细胞24小时，抑制了细胞活力和迁移[5]。用10µM 的Corylin预处理BV2细胞1小时，减轻了脂多糖（LPS）诱导的炎症反应，减少了TNF-α和IL-6的产生，并抑制了MAPK磷酸化[6]。
在体内，每日口服给予50mg/kg剂量的Corylin，持续15周，降低了高胆固醇饮食处理小鼠胸主动脉的氧化应激、VCAM-1和NOX4表达以及动脉粥样硬化斑块[7]。单次腹腔注射20mg/kg剂量的Corylin（12小时），显著减轻了LPS诱导的小鼠心功能障碍并减少了炎症[8]。