Competence-Stimulating Peptide-2 (CSP-2) is a quorum-sensing signaling peptide produced by Streptococcus pneumoniae. Competence-Stimulating Peptide-2 activates bacterial competence by binding to compatible receptor ComD2 (EC50 of 50.7nM), thereby promoting the uptake of exogenous DNA and genetic transformation. Competence-Stimulating Peptide-2 can be used in studies related to quorum sensing, genetic transformation, and biofilm formation in Streptococcus pneumoniae, Streptococcus mitis, and Streptococcus oralis[1-4].
References:
[1] Zhang Y, Guo S, Li Y, et al. Competence Regulation in Streptococcus pneumoniae and the Competence-targeted Anti-pneumococcal Strategies. Curr Med Chem. 2025;32(34):7564-7576.
[2] Yang Y, Cornilescu G, Tal-Gan Y. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry. 2018 Sep 11;57(36):5359-5369.
[3] Pourhajibagher M, Alaeddini M, Etemad-Moghadam S, et al. Quorum quenching of Streptococcus mutans via the nano-quercetin-based antimicrobial photodynamic therapy as a potential target for cariogenic biofilm. BMC Microbiol. 2022 May 10;22(1):125.
[4] Bradshaw JL, Rafiqullah IM, Robinson DA, et al. Transformation of nonencapsulated Streptococcus pneumoniae during systemic infection. Sci Rep. 2020 Nov 3;10(1):18932.
Competence-Stimulating Peptide-2 (CSP-2)是一种由肺炎链球菌产生的群体感应信号肽。Competence-Stimulating Peptide-2通过与兼容受体ComD2结合（EC50=50.7nM）来激活细菌的感受态，从而促进外源DNA的摄取和遗传转化。Competence-Stimulating Peptide-2可用于肺炎链球菌、轻度链球菌和口腔链球菌的群体感应、遗传转化及生物膜形成等相关研究[1-4]。