Clofazimine-d7

Clofazimine-d₇ is intended for use as an internal standard for the quantification of clofazimine by GC- or LC-MS. Clofazimine is an antimycobacterial compound with MICs ranging from 0.03 to 0.12 μg/ml against clinical isolates of M. paratuberculosis.¹ It also has activity against 80 isolates of M. fortuitum, M. chelonae, and M. fallax (MICs = ≤0.25-8 μg/ml).² Clofazimine (25 mg/kg per day) reduces the number of M. tuberculosis-infected cells in the spleen and lungs of mice infected with the multidrug-resistant clinical isolate strain CNL.³ Formulations containing clofazimine have been used for the treatment of leprosy and drug-resistant tuberculosis.⁴