Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
Claramine (2-20 μM; 20 h) does not affect cell viability in human neuroblastoma cells (SH-SY5Y) at concentrations below 10 μM. Similarly, Claramine (2-20 μM; 20 h) does not impact cell activity in HEK293 cells[1].
Claramine (2.5-10 μM; 20 h) protects human neuroblastoma (SH-SY5Y) cells from the harmful effects of pore-forming agents, melittin (4 μM; 20 h) and α-hemolysin (50 μg/mL; 20 h), by inhibiting their binding to cell membranes[1].
References:
[1]. Kreiser RP, et al. A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents. ACS Chem Neurosci. 2022;13(8):1219-1231.