CL15F6 is an ionizable cationic lipid (pKa = 6.75).[1] It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA and polymer-lipid hybrid nanoparticles for the delivery of plasmid DNA in vitro.[1],[2]
References:
[1].Younis, M.A., Sato, Y., Elewa, Y.H.A., et al.Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosisJ. Control. Release353685-698(2023).
[2].Maeki, M., Uno, S., Sugiura, K., et al.Development of polymer-lipid hybrid nanoparticles for large-sized plasmid DNA transfectionACS Appl. Mater. Interfaces16(2)2110-2119(2024).
















