CK-963 is an activator for cardiac troponin (cTnC) with Ki of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats.
CK-963 (0.5 mg/kg, i.v.) reveals a pharmacokinetic profil with a clearance <25% in hepatic blood flow and a half-time of 0.6 h in Sprague-Dawley rats[1].Pharmacokinetic Analysis in SD rats Model[1]
References:
[1]. Collibee SE, et al., Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats. J Med Chem. 2024 Mar 7.