Citrullinated Fibrinogen (β chain) (R44 + R47 + R60) (41-62)-biotin Peptide

Citrullinated fibrinogen (β chain) (R44 + R47 + R60) (41-62)-biotin peptide is a biotinylated version of a tri-citrullinated form of the secreted matrix protein fibrinogen, which has been found as the citrullinated form in plasma circulating immune complexes of patients with rheumatoid arthritis.¹ Fibrinogen is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) and PAD4, which can occur in the synovial fluid from patients with rheumatoid arthritis.^2,3 's Citrullinated Fibrinogen (β Chain) (R44 + R47 + R60) (41-62)-biotin Peptide is intended for the detection of autoantibodies against fibrinogen citrullinated at R44, R47, and R60.