Zuclomiphene-d4 (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active pocholesterolemic agent[1][2][3][4].
[1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50.
[2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6.
[3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenyletlene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8.
[4]. Ramsey RB, et al. The biochemical and morphological response of drolytic enzymes in the developing brain to pocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.