Chrysoeriol is a flavonoid that has been found in Capsicum and has diverse biological activities.1,2,3,4 It is active against the Gram-positive bacteria E. faecalis, B. subtilis, and S. aureus (MICs = 1, 1, and 0.25 ?g/ml, respectively) and the Gram-negative bacteria P. aeruginosa, K. pneumoniae, and E. coli (MICs = 0.12, 0.25, and 0.06 ?g/ml, respectively).1 Chrysoeriol (7.5, 15, and 30 ?M) induces cell cycle arrest at the G1 phase and autophagy in A549 lung cancer cells.2 It reduces LPS-induced production of IL-6, IL-1β, and TNF-α in RAW 264.7 cells when used at a concentration of 20 ?M.3 Chrysoeriol (20 mg/kg) reduces plasma glucose, total cholesterol, free fatty acid, and phospholipid levels in a rat model of diabetes induced by streptozotocin .4
1.Nascimento, P.L.A., Nascimento, T.C.E.S., Ramos, N.S.M., et al.Quantification, antioxidant and antimicrobial activity of phenolics isolated from different extracts of Capsicum frutescens (pimenta malagueta)Molecules19(4)5434-5447(2014) 2.Wei, W., He, J., Ruan, H., et al.In vitro and in vivo cytotoxic effects of chrysoeriol in human lung carcinoma are facilitated through activation of autophagy, sub-G1/G0 cell cycle arrest, cell migration and invasion inhibition and modulation of MAPK/ERK signalling pathwayJ. BUON24(3)936-942(2019) 3.Wu, J.-Y., Chen, Y.-J., Bai, L., et al.Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathwaysPhytomedicine68153173(2020) 4.Baskaran, K., Pugalendi, K.V., and Saravanan, R.Antidiabetic and antihyperlipidemic activity of chrysoeriol in diabetic rats, role of HMG CoA reductase, LCAT and LPL: In vivo and in silico approachesJ. Pharm. Res.9(9)597-605(2015)