Choline-d9 is intended for use as an internal standard for the quantification of choline by GC- or LC-MS. Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis.1,2,3,4 It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport.1 Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats.2 Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm.3 Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.4
1.Sanders, L.M., and Zeisel, S.H.Choline: Dietary requirements and role in brain developmentNutr. Today42(4)181-186(2007) 2.Thomas, J.D., Garrison, M., and O’Neill, T.M.Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in ratsNeurotoxicol. Teratol.26(1)35-45(2004) 3.Derbyshire, E., and Obeid, R.Choline, neurological development and brain function: A systematic review focusing on the first 1000 daysNutrients12(6)1731(2020) 4.Moretti, A., Paoletta, M., Liguori, S., et al.Choline: An essential nutrient for skeletal muscleNutrients12(7)E2144(2020)