Chemerin-9 is a peptide agonist of chemokine-like receptor 1 (CMKLR1) and CMKLR2, also known as chemerin receptor 1 (chemerin1) and chemerin2, respectively.1 It is composed of nine C-terminal amino acids of the endogenous human protein chemerin, a chemotactic protein and adipokine involved in the early immune response and energy homeostasis.2 Chemerin-9 binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively, in a radioligand binding assay) and induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Gα15 when used at a concentration of 1 µM.3
1.Wittamer, V., GrÉgoire, F., Robberecht, P., et al.The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potencyJ. Biol. Chem.279(11)9956-9962(2004) 2.Fischer, T.F., and Beck-Sickinger, A.G.Chemerin - exploring a versatile adipokineBiol. Chem.403(7)625-642(2022) 3.Barnea, G., Strapps, W., Herrada, G., et al.The genetic design of signaling cascades to record receptor activationProc. Natl. Acad. Sci. USA105(1)64-69(2008)