GlpBio

CGRP (8-37) (mouse, rat) (trifluoroacetate salt)

目录号: GC52438纯度: >95.00%同义词: Calcitonin Gene-Related Peptide (8-37), CGRP8-37, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
A CGRP receptor antagonist
CGRP (8-37) (mouse, rat) (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥7,364.00现货
1
5 mg¥14,980.00现货
1
500 μg¥4,606.00现货
1
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产品描述 Description

Calcitonin gene-related protein (CGRP) (8-37) is a CGRP receptor antagonist.1 It corresponds to amino acids 8-37 of rodent α-CGRP , a neuropeptide. CGRP (8-37) selectively binds to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP3 (IC50s = 1 and 6.2 nM, respectively) over a complex of CRLR and RAMP2 (IC50 = 219 nM). It prevents CGRP-induced increases in heart rate and decreases in blood pressure in transgenic mice expressing rat CRLR in smooth muscle-containing tissues and sympathetic ganglia when administered at a dose of 2 µmol/kg.2 CGRP (8-37) also inhibits p-phenylquinone-induced writhing (ED50 = 6 µg/animal) and decreases body temperature in a dose-dependent manner in mice.3

1.Husmann, K., Born, W., Fischer, J.A., et al.Three receptor-activity-modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cellsBiochem. Pharmacol.66(11)2107-2115(2003) 2.Kunz, T.H., Scott, M., Ittner, L.M., et al.Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activityAm. J. Physiol. Heart Circ. Physiol.293(4)H2155-H2160(2007) 3.Saxen, M.A., Smith, F.L., Dunlow, L.D., et al.The hypothermic and antinociceptive effects of intrathecal injection of CGRP (8-37) in miceLife Sci.55(21)1665-1674(1994)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
Calcitonin Gene-Related Peptide (8-37), CGRP8-37, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
SMILES
OC(C(F)(F)F)=O.CC(C)[C@H](N[H])C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N2CCC[C@H]2C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)=O)=O
分子式
C138H224N42O41 ? XCF3COOH
分子量
3127.5 g/mol
溶解性
PBS (pH 7.2): 2 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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g/mol