Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities.1,2 It is cytotoxic to KB and NCI H187 cancer cells (IC50s = 1.92 and 1.24 µg/ml).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.2
1.Laphookhieo, S., Cheenpracha, S., Karalai, C., et al.Cytotoxic cardenolide glycoside from the seeds of Cerbera odollamPhytochemistry65(4)507-510(2004) 2.Menezes, R.G., Usman, M.S., Hussain, S.A., et al.Cerbera odollam toxicity: A reviewJ. Forensic Leg. Med.58113-116(2018)