Cephalosporin C is a fungal metabolite and cephalosporin antibiotic that has been found in Cephalosporium.1 It is active against a variety of bacteria, including S. pyogenes, C. diphtheriae, E. coli, and H. influenzae (MICs = 31, 15.6, 125, and 31 ?g/ml, respectively), as well as clinical isolates of N. gonorrhoeae (MICs = 1.9-15.6 ?g/ml).2 Formulations containing cephalosporin C have been used in the treatment of various bacterial infections.
1.Newton, G.G., and Abaham, E.P.Cephalosporin C, a new antibiotic containing sulphur and D-alpha-aminoadipic acidNature175(4456)548(1955) 2.Jago, M., and Heatley, N.G.Some biological properties of cephalosporin C and a derivativeBr. J. Pharmacol. Chemother.16(2)170-179(1961)