Cephacetrile is a cephalosporin antibiotic.1 It is active against numerous Gram-positive and Gram-negative bacteria, including clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, and Klebsiella (MICs = 0.64, 0.64, 0.16, 6.25 and 3.12 µg/ml, respectively). Cephacetrile (30 µg/disc) is also active against veterinary isolates of S. aureus from bovine mastitis.2 Formulations containing cephacetrile have been used in the treatment of bovine mastitis.
1.Neu, H.C., and Winshell, E.B.In vitro evaluation of cephacetrile, a new cephalosporin antibioticJ. Antibiot. (Tokyo)25(7)400-404(1972) 2.Costa, E.O., Benites, N.R., Guerra, J.L., et al.Antimicrobial susceptibility of Staphylococcus spp. isolated from mammary parenchymas of slaughtered dairy cowsJ. Vet. Med. B Infect. Dis. Vet. Public Health47(2)99-103(2000)