Cefepime Dihydrochloride Monohydrate is a broad-spectrum cephalosporin with enhanced coverage against Gram-positive and Gram-negative bacteria [1]. Cefepime Dihydrochloride Monohydrate exerts the antimicrobial effect by attaching to specific penicillin-binding proteins, disrupting cell-wall synthesis[2]. Cefepime Dihydrochloride Monohydrate has been widely used as a model compound to investigate the degradation status in stress stability studies[3].
References:
[1] Neu H C. Safety of cefepime: a new extended-spectrum parenteral cephalosporin[J]. The American Journal of Medicine, 1996, 100(6): 68S-75S.
[2] Okamoto M P, Nakahiro R K, Chin A, et al. Cefepime: a new fourth-generation cephalosporin[J]. American Journal of Health-System Pharmacy, 1994, 51(4): 463-477.
[3] Kumar V J, Gupta P B, Kumar K S R P, et al. Identification and characterization of new degradation products of cefepime dihydrochloride monohydrate drug substance during stress stability studies[J]. Analytical Sciences, 2010, 26(10): 1081-1086.
Cefepime Dihydrochloride Monohydrate是一种广谱头孢菌素，对革兰氏阳性菌和革兰氏阴性菌的覆盖范围较广[1]。Cefepime Dihydrochloride Monohydrate通过附着于特定的青霉素结合蛋白，破坏细胞壁合成，从而发挥抗菌作用[2]。Cefepime Dihydrochloride Monohydrate已被广泛用作模型化合物，用于研究其在强制稳定性试验中的降解状况[3]。