Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity[1].Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment[2].
Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3]. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3]
[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11. [2]. 3.Kawada A, et al. Drug eruption induced by cefcapene pivoxil hydrochloride.Contact Dermatitis. 2001 Mar;44(3):197. [3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15.