Carubicin is an anthracycline originally isolated from A. carminata that has anticancer activity.1,2 It is cytotoxic to MCF-7 and K562 cells (IC50s = 90 and 60 nM, respectively), as well as P-glycoprotein-expressing MCF-7/DOX and K562i/S9 cells (IC50s = 90 and 60 nM, respectively).1
1.Tevyashova, A.N., Shtil, A.A., Olsufyeva, E.N., et al.Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variantsJ. Antibiot. (Tokyo)57(2)143-150(2004) 2.Gause, G.F., Brazhnikova, M.G., and Shorin, V.A.A new antitumor antibiotic, carminomycin (NSC-180024)Cancer Chemother. Rep.58(2)255-256(1974)