Carnosine conjugated alyronate is a aluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated alyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated alyronate against amyloid aggregation is directly proportional to the Carnosine loading.
References:
[1]. Greco V, et al. aluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Sci Rep. 2020 Sep 29;10(1):15998.