Carcinoembryonic antigen (CEA) is a tumor marker in lung cancer.
Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. The use of CEA as a prognostic and predictive marker. CEA is a glycoprotein involved in cell adhesion, and is normally produced during fetal development but the production stops before birth. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells[1].
[1]. Grunnet M, et al. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 2012 May;76(2):138-43.