Carbofuran-d3

Carbofuran-d₃ is intended for use as an internal standard for the quantification of carbofuran by GC- or LC-MS. Carbofuran is a carbamate insecticide that inhibits acetylcholinesterase (AChE) in insects and mammals (K_as = 9.4, 30, and 210 µM for M. domestica brain, A. mellifera brain, and bovine erythrocyte AChE, respectively).¹ It also inhibits AChE from rat and human erythrocytes with IC₅₀ values of 40 and 25 nM, respectively.² It is toxic to the housefly M. domestica (LD₅₀ = 4.6 mg/kg) and fourth-instar larvae of the mosquito C. pipiens with an LC₅₀ value of 0.054 ppm. Carbofuran is toxic to birds, rats (LD₅₀ = 4-11 mg/kg), and other mammals, including dogs, sheep, and cattle, and is considered an environmental toxin.^1,3 Formulations containing carbofuran have been used in agriculture for the control of insects, nematodes, mites, and ticks.