IC50: 0.4 μM (CamA)[1]
Kd: 0.2 μM (CamA)[1]
CamA-IN-1 is a Clostridioides difficile-specific DNA adenine metltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC50 and Kd values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI)[1].
CamA-IN-1 (compound 39) 对 CamA 具有抑制作用，IC50 和 Kd 值分别为 0.4 μM 和 0.2 μM[1] .
相对于密切相关的细菌和哺乳动物 DNA 和 RNA 转移酶、蛋白质赖氨酸和精氨酸转移酶以及人类腺苷受体，CamA-IN-1 对 CamA 具有选择性[1]。
[1]. Jujun Zhou, et al. Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Metltransferase Required for Normal Sporulation and Persistence. J Med Chem. 2023 Jan 12;66(1):934-950.