Calcitonin salmon (Salmon calcitonin) is a calcitonin drug derived from salmon [1]. Calcitonin salmon is used to treat bone metabolism disorders and has the effects of inhibiting bone resorption and lowering blood calcium [2-3].
In Articular cartilage explants, Calcitonin salmon (0.1-100nM; 16d) stimulates proteoglycan synthesis in human articular cartilage explants [4]. In C6 cells, all concentrations of Calcitonin salmon (3µg/mL, 6µg/mL, 12µg/mL, 25µg/mL, 50µg/mL; 1h) significantly enhanced cell viability after glutamate-induced cytotoxicity [5]. In HBV-163 cells, Calcitonin salmon (0.03-3mU/mL; 48h) increases the concentration of insulin-like growth factors in serum-free cultures of human osteoblast-line cells [6]. In SH-SY5Y cells, treatment with Calcitonin salmon (50nM, 100nM; 24h) inhibit cell viability [7].
In male mice, acute Calcitonin salmon (5μg/kg; ip; single injection) administration attenuates nicotine-induced locomotor stimulation and dopamine release in the NAc shell [8]. In animal model of type 2 diabetes, oral administration of Calcitonin salmon (0.5mg/kg, 1mg/kg, 2mg/kg; po; 10 weeks) attenuated the development of hyperglycemia in severely diabetic zucker diabetic fatty rats in a dose-dependent manner [1]. In CD1 male mice, Calcitonin salmon (2.5IU/kg; ip; single injection) can enhance the analgesic effect of antidepressants that reduce 5-HT uptake [9]. In male albino mice CD1, injection of Calcitonin salmon (40IU/kg; ip; single injection) induces analgesia in mice [10].
References:
[1]. Feigh M, Andreassen KV, Neutzsky‐Wulff AV, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta‐cell area and function in Zucker diabetic fatty rats. British journal of pharmacology. 2012 Sep; 167(1): 151-163.
[2]. Chesnut C3, Azria M, Silverman S, et al. Salmon calcitonin: a review of current and future therapeutic indications. Osteoporosis international. 2008 Apr; 19: 479-491.
[3]. Wisneski LA. Salmon calcitonin in the acute management of hypercalcemia. Calcified tissue international. 1990 Jan; 46: S26-30.
[4]. Sondergaard BC, Madsen SH, Segovia-Silvestre T, et al. Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes. BMC musculoskeletal disorders. 2010 Dec; 11: 1-10.
[5]. Taskiran AS, Ergul M. The effect of salmon calcitonin against glutamate-induced cytotoxicity in the C6 cell line and the roles the inflammatory and nitric oxide pathways play. Metabolic Brain Disease. 2021 Oct; 36(7): 1985-1993.
[6]. Farley J, Dimai HP, Stilt-Coffing B, et al. Calcitonin increases the concentration of insulin-like growth factors in serum-free cultures of human osteoblast-line cells. Calcified tissue international. 2000 Sep; 67: 247-254.
[7]. Varol I, Karabork S, Cetinkaya A. Anti-proliferative effects of salmon calcitonin on SH-SY5Y neuroblastoma in vitro. Experimental Biomedical Research. 2023; 6(1): 6.
[8]. Aranäs C, Vestlund J, Witley S, et al. Salmon calcitonin attenuates some behavioural responses to nicotine in male mice. Frontiers in Pharmacology. 2021 Jun 21; 12: 685631.
[9]. Ormazábal MJ, Goicoechea C, Sánchez E, et al. Salmon calcitonin potentiates the analgesia induced by antidepressants. Pharmacology Biochemistry and Behavior. 2001 Jan 1; 68(1): 125-133.
[10]. Colado MI, Ormazabal MJ, Goicoechea C, et al. Involvement of central serotonergic pathways in analgesia elicited by salmon calcitonin in the mouse. European journal of pharmacology. 1994 Feb 11;252(3): 291-297.
Calcitonin salmon (Salmon calcitonin)是一种从鲑鱼中提取的降钙素类药物 [1]。Calcitonin salmon用于治疗骨代谢紊乱，具有抑制骨吸收、降低血钙的作用 [2-3]。
在关节软骨外植体中，Calcitonin salmon（0.1-100nM；16d）可刺激人关节软骨外植体中的蛋白多糖合成 [4]。在C6细胞中，所有浓度的鲑鱼降钙素（3µg/mL、6µg/mL、12µg/mL、25µg/mL、50µg/mL；1h）均显著增强谷氨酸诱导的细胞毒性后的细胞活力 [5]。在HBV-163细胞中，Calcitonin salmon（0.03-3mU/mL；48h）可增加人成骨细胞无血清培养物中胰岛素样生长因子的浓度 [6]。在SH-SY5Y细胞中，Calcitonin salmon（50nM、100nM；24h）处理可抑制细胞活力 [7]。
在雄性小鼠中，急性给予Calcitonin salmon（5μg/kg；ip；单次注射）可减弱尼古丁诱导的运动刺激和NAc壳中的多巴胺释放 [8]。在2型糖尿病动物模型中，口服Calcitonin salmon（0.5mg/kg、1mg/kg、2mg/kg；po；10周）可剂量依赖性地减缓重度糖尿病Zucker型糖尿病肥胖大鼠的高血糖发展 [1]。在CD1雄性小鼠中，Calcitonin salmon（2.5IU/kg；ip；单次注射）可增强降低5-HT摄取的抗抑郁药的镇痛作用 [9]。在CD1雄性白化小鼠中，注射鲑鱼降钙素（40IU/kg；ip；单次注射）可诱导小鼠镇痛 [10]。