C18 Sphingomyelin is a naturally occurring form of sphingomyelin. C18 Sphingomyelin is increased by approximately 35-fold in CCD-112 colon fibroblasts compared with HCT116 human colorectal carcinoma cells.[1] C18 Sphingomyelin has been used as an internal standard for the quantification of sphingolipid metabolites.[2] This product is a mixture of the D-erythro and L-threo isomers of C18 sphingomyelin.
Reference:
[1]. del Solar, V., Lizardo, D.Y., Li, N., et al. Differential regulation of specific sphingolipids in colon cancer cells during staurosporine-induced apoptosis. Chem. Biol. 22(12), 1662-1670 (2015).
[2]. Mano, N., Oda, Y., Yamada, K., et al. Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. Anal. Biochem. 244(2), 291-300 (1997).