C18 dihydro Ceramide (d18:0/18:0)是一种生物活性鞘脂，也是缺乏4,5-反式双键的C18 ceramide从头合成的前体。
Cas No.:2304-80-5
Sample solution is provided at 25 µL, 10mM.
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C18 dihydro Ceramide (d18:0/18:0) is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond[1]. Upon desaturase catalysis, C18 dihydro Ceramide (d18:0/18:0) is converted into mature C18 ceramide (Cer; N-stearoyl-sphingosine (d18:1/18:0)), which functions as a key signaling molecule regulating apoptosis, autophagy, and insulin resistance[2][3][4]. C18 dihydro Ceramide (d18:0/18:0) is abnormally elevated in NAFLD, plasma from pre-diabetic patients, and skin from atopic dermatitis patients and has the potential to serve as an early disease biomarker and therapeutic target[5][6][7].
References:
[1] Mikami T, Kashiwagi M, Tsuchihashi K, Akino T, Gasa S. Substrate specificity and some other enzymatic properties of dihydroceramide desaturase (ceramide synthase) in fetal rat skin. J Biochem. 1998;123(5):906-911.
[2] Oleinik NV, Atilgan FC, Kassir MF, et al. Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. Cancer Res. 2025;85(17):3313-3334.
[3] Oleinik N, Albayram O, Kassir MF, et al. Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects. Aging Cell. 2023;22(10):e13954.
[4] Koch A, Grammatikos G, Trautmann S, et al. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci. 2017;18(7):1532.
[5] Lee AY, Lee JW, Kim JE, et al. Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model. Biochem Biophys Res Commun. 2017;494(3-4):460-469.
[6] Wigger L, Cruciani-Guglielmacci C, Nicolas A, et al. Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell Rep. 2017;18(9):2269-2279.
[7] Joo KM, Hwang JH, Bae S, et al. Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins. J Dermatol Sci. 2015;77(1):71-74.
C18 dihydro Ceramide (d18:0/18:0)是一种生物活性鞘脂，也是缺乏4,5-反式双键的C18 ceramide从头合成的前体[1]。在去饱和酶催化下，C18 dihydro Ceramide (d18:0/18:0)转化为成熟的C18 ceramide（Cer；N-硬脂酰鞘氨醇（d18:1/18:0）），其作为关键信号分子，调控细胞凋亡、自噬和胰岛素抵抗[2][3][4]。C18 dihydro Ceramide (d18:0/18:0)在非酒精性脂肪肝病（NAFLD）、糖尿病前期患者血浆以及特应性皮炎患者皮肤中异常升高，具有作为早期疾病生物标志物和治疗靶点的潜力[5][6][7]。
| Cas No. | 2304-80-5 | SDF | |
| 别名 | 二羟基神经酰胺,Cer(d18:0/18:0) | ||
| 化学名 | N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide | ||
| Canonical SMILES | O=C(CCCCCCCCCCCCCCCCC)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC | ||
| 分子式 | C36H73NO3 | 分子量 | 568 |
| 溶解度 | DMSO: Soluble,Ethanol: Warmed | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7606 mL | 8.8028 mL | 17.6056 mL |
| 5 mM | 352.1 μL | 1.7606 mL | 3.5211 mL |
| 10 mM | 176.1 μL | 880.3 μL | 1.7606 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet