GlpBio

C14-O2

目录号: GC91596纯度: >95.00%
C14-O2 is an ionizable cationic lipid (apparent pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.
C14-O2
Cas No.: 2639634-77-6
规格价格库存数量操作
1 mg¥1,386.00现货
1
5 mg¥4,158.00现货
1
10 mg¥6,244.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

C14-O2 is an ionizable cationic lipid (apparent pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing C14-O2 and encapsulating mRNA encoding chimeric antigen receptor (CAR) induce CAR expression and B cell aplasia in mice.

References:
[1].Mukalel, A.J., Hamilton, A.G., Billingsley, M.M., et al.Oxidized mRNA lipid nanoparticles for in situ chimericantigen receptor monocyte engineeringAdv. Funct. Mater.Online ahead of print2312038(2024).

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

CAS 号
2639634-77-6
分子式
C88H181N5O9
分子量
1453.4 g/mol
溶解性
DMSO: Sparingly soluble: 1-10 mg/ml,Ethanol: Sparingly soluble: 1-10 mg/ml,PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol