BRC4wt (trifluoroacetate salt)

BRC4wt is an acetylated peptide derived from the BRC4 repeat in human BRCA2 (1521-1536) and an inhibitor of the protein-protein interaction between BRCA2 and RAD51.¹ When coupled to the cationic cell-penetrating peptide (Arg)₉ , BRC4wt shortens DNA replication tract lengths and reduces homologous repair frequency of DNA damage induced by the DNA topoisomerase I inhibitor camptothecin in vitro, as well as potentiates cell death induced by the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib in HeLa human cervical cancer and U2OS human osteosarcoma cells but not in non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells.