Bradykinin fragment (1-5) is a metabolite of the endogenous vasodilator bradykinin .1 It is formed from bradykinin by angiotensin-converting enzyme (ACE). Bradykinin fragment (1-5) (100 nM) increases the production of nitric oxide (NO) in neonatal rat cardiomyocytes.2 It inhibits α-thrombin-induced platelet aggregation of washed isolated platelets (IC50 = 0.5 mM).3 Bradykinin fragment (1-5) prevents decreases in mean arterial blood pressure and heart rate and increases survival in a rat model of LPS-induced septicemia.4
1.Bujak-Gi?ycka, B., Olszanecki, R., Madej, J., et al.Metabolism of bradykinin in aorta of hypertensive ratsActa Biochim. Pol.58(2)199-202(2011) 2.Souza-Silva, I.M., de Paula, C.A., Bolais-Amos, L., et al.Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptorsBr. J. Pharmacol.179(12)3061-3077(2022) 3.Hasan, A.A.K., Amenta, S., and Schmaier, A.H.Bradykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of α-thrombin-induced platelet activationCirculation94(3)517-528(1996) 4.Morinelli, T.A., Webb, J.G., Jaffa, A.A., et al.A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in ratsJ. Pharmacol. Exp. Ther.296(1)71-76(2001)