| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5mg | ¥540.00 | 现货 | 1 | |
| 10mg | ¥855.00 | 现货 | 1 | |
| 25mg | ¥1,800.00 | 现货 | 1 | |
| 50mg | ¥2,700.00 | 现货 | 1 | |
| 100mg | ¥4,050.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥594.00 | 现货 | 1 |
BQR-695 is an antimalarial compound.1 It inhibits recombinant P. vivax and human phosphatidylinositol 4-kinase (PI4K; IC50s = 3.5 and 90 nM, respectively). BQR-695 induces schizont-stage arrest and death of P. falciparum (IC50 = ~70 nM) without inducing cytotoxicity in mature red blood cells (RBCs).
1.McNamara, C.W., Lee, M.C., Lim, C.S., et al.Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malariaNature504(7479)248-253(2013)
Cell experiment: | A clonal population of P. falciparum Dd2 parasites is used to initiate two or three independent parasite cultures under the initial selection pressure of 12 nM KAI407, 1 nM KAI715 or 40 nM BQR695. Stepwise drug evolution continues until the final concentration is at least 3-fold higher than the initial concentration (typically 80 to 120 days). For each of the ten resistant strains, copy number variations (CNVs) and single nucleotide variations (SNVs) are detected using a whole-genome tiling array and analyzed with PfGenominator. The susceptibility of each resistant strain to KAI407, KAI715, KDU691 and BQR695 is determined by the 72-hr SYBR Green cell proliferation assay with four independent experiments assayed in duplicate[2]. |
References: [1]. Fowler ML, et al. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Sci. 2016 Apr;25(4):826-39. |
