Bosentan-d4 is an internal standard for the quantification of bosentan by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).1,2
1.Jae, H.S., Winn, M., Dixon, D.B., et al.Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonistsJ. Med. Chem.40(20)3217-3227(1997) 2.Wu, C., Decker, E.R., Blok, H., et al.Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)-thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonistJ. Med. Chem.47(8)1969-1986(2004)