BNN6 is a thermally responsive NO donor that can be effectively combined with Photothermal therapy (PTT) [1]. BNN6 can decompose under high temperature or strong light conditions, releasing NO, exhibiting cytotoxicity towards tumor cells[2]. BNN6 can assemble with lignin to form micellar nanoparticles. Under visible light irradiation, it exhibits excellent antibacterial effects against both Gram-negative and Gram-positive bacteria[3]. BNN6 can be used to prepare photo-activated antibacterial nanocomposite hydrogels, which have significant anti-inflammatory effects. They can promote collagen deposition, stimulate angiogenesis, and thereby accelerate wound healing[4]. BNN6 can be combined with graphdiyne (GDY) nanozymes to form a complex that targets the inflammation in the corneal area, inhibits the inflammatory response, and effectively induces bacterial apoptosis, without causing cytotoxicity or hemolytic activity[5].
References:
[1] Xin Y, Yu Y, Su M, et al. In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment[J]. Journal of Controlled Release, 2023, 359: 69-84.
[2] Luo X, Zhao T, Qin S, et al. Multifunctional metal–organic frameworks with photothermal-triggered nitric oxide release for gas/photothermal synergistic cancer therapy[J]. Journal of Colloid and Interface Science, 2025, 684: 47-59.
[3] Li X, Zhang Q, Wu W, et al. Lignin-Based Visible Light-Triggered Nitric Oxide Nanogenerator for Antibacterial Applications[J]. Biomacromolecules, 2024, 25(10): 6624-6634.
[4] Yang J, Jia D, Qiao J, et al. Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@ BNN6 Encapsulated in GelMA Hydrogel[J]. International Journal of Nanomedicine, 2024: 11499-11516.
[5] Zhang D, Yu L, Meng F, et al. Graphdiyne-based nanoplatforms as reactive oxygen species and nitric oxide generators for synergistic infectious keratitis therapy[J]. Chemical Engineering Journal, 2025: 168125.
BNN6是一种热响应型一氧化氮供体，可有效地与光热疗法（PTT）相结合[1]。BNN6在高温或强光条件下能够分解，释放一氧化氮，对肿瘤细胞表现出细胞毒性[2]。BNN6可与木质素组装形成胶束纳米颗粒，在可见光照射下，该复合体对革兰氏阴性菌和革兰氏阳性菌均表现出优异的抗菌效果[3]。BNN6可用于制备光激活抗菌纳米复合水凝胶，该凝胶具有显著的抗炎作用，能促进胶原蛋白沉积、刺激血管生成，从而加速伤口愈合[4]。BNN6可与graphdiyne（GDY）纳米酶结合形成复合物，靶向角膜区域的炎症，抑制炎症反应，并有效诱导细菌凋亡，同时不引起细胞毒性或溶血活性[5]。