BNN6是一种热响应型一氧化氮供体，可有效地与光热疗法（PTT）相结合。
Cas No.:106476-75-9
Sample solution is provided at 25 µL, 10mM.
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BNN6 is a thermally responsive NO donor that can be effectively combined with Photothermal therapy (PTT) [1]. BNN6 can decompose under high temperature or strong light conditions, releasing NO, exhibiting cytotoxicity towards tumor cells[2]. BNN6 can assemble with lignin to form micellar nanoparticles. Under visible light irradiation, it exhibits excellent antibacterial effects against both Gram-negative and Gram-positive bacteria[3]. BNN6 can be used to prepare photo-activated antibacterial nanocomposite hydrogels, which have significant anti-inflammatory effects. They can promote collagen deposition, stimulate angiogenesis, and thereby accelerate wound healing[4]. BNN6 can be combined with graphdiyne (GDY) nanozymes to form a complex that targets the inflammation in the corneal area, inhibits the inflammatory response, and effectively induces bacterial apoptosis, without causing cytotoxicity or hemolytic activity[5].
References:
[1] Xin Y, Yu Y, Su M, et al. In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment[J]. Journal of Controlled Release, 2023, 359: 69-84.
[2] Luo X, Zhao T, Qin S, et al. Multifunctional metal–organic frameworks with photothermal-triggered nitric oxide release for gas/photothermal synergistic cancer therapy[J]. Journal of Colloid and Interface Science, 2025, 684: 47-59.
[3] Li X, Zhang Q, Wu W, et al. Lignin-Based Visible Light-Triggered Nitric Oxide Nanogenerator for Antibacterial Applications[J]. Biomacromolecules, 2024, 25(10): 6624-6634.
[4] Yang J, Jia D, Qiao J, et al. Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@ BNN6 Encapsulated in GelMA Hydrogel[J]. International Journal of Nanomedicine, 2024: 11499-11516.
[5] Zhang D, Yu L, Meng F, et al. Graphdiyne-based nanoplatforms as reactive oxygen species and nitric oxide generators for synergistic infectious keratitis therapy[J]. Chemical Engineering Journal, 2025: 168125.
BNN6是一种热响应型一氧化氮供体，可有效地与光热疗法（PTT）相结合[1]。BNN6在高温或强光条件下能够分解，释放一氧化氮，对肿瘤细胞表现出细胞毒性[2]。BNN6可与木质素组装形成胶束纳米颗粒，在可见光照射下，该复合体对革兰氏阴性菌和革兰氏阳性菌均表现出优异的抗菌效果[3]。BNN6可用于制备光激活抗菌纳米复合水凝胶，该凝胶具有显著的抗炎作用，能促进胶原蛋白沉积、刺激血管生成，从而加速伤口愈合[4]。BNN6可与graphdiyne（GDY）纳米酶结合形成复合物，靶向角膜区域的炎症，抑制炎症反应，并有效诱导细菌凋亡，同时不引起细胞毒性或溶血活性[5]。
| Cas No. | 106476-75-9 | SDF | |
| 分子式 | C14H22N4O2 | 分子量 | 278.35 |
| 溶解度 | DMSO : 175 mg/mL (628.70 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5926 mL | 17.963 mL | 35.926 mL |
| 5 mM | 718.5 μL | 3.5926 mL | 7.1852 mL |
| 10 mM | 359.3 μL | 1.7963 mL | 3.5926 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet