BMS-195270 is a small molecule that inhibits Carbachol -evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux.
BMS-195270 (3 μM) produces a dramatic reduction in developed pressure at infusion volumes of 0.2-1.3 mL and inhibits spontaneous contractions in an ex vivo rat whole bladder model[1].
BMS-195270 (2.8 mM) results adult worms of C. elegans displaying an Egl-d phenotype, as well as slowed or arrested pharyngeal pumping (Eat), and uncoordinated motion (Unc)[1].
BMS-195270 inhibits the response of HEK293 cells to the muscarinic agonist Carbachol with an EC50 of 2 μM[1].
BMS-195270 inhibits calcium flux, and retains inhibitory activity even when endogenous calcium channels are inactivated[1].