Biotin-PEG4-alkyne is a functionalized compound that combines biotin, a tetraethylene glycol (PEG4) linker, and a terminal alkyne group. Biotin-PEG4-alkyne can efficiently conjugate with azide groups via click chemistry to form a stable triazole bond, while the PEG4 chain enhances water solubility and biocompatibility to reduce nonspecific binding and steric hindrance. Biotin-PEG4-alkyne can be used in research related to biolabeling, drug delivery systems, and PROTAC molecule construction[1-4].
References:
[1] Wang YC, Kelso AA, Karamafrooz A, et al. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Cell Rep. 2023 Apr 25;42(4):112296.
[2] Park J, Wu J, Szkop KJ, et al. SMYD5 methylation of rpL40 links ribosomal output to gastric cancer. Nature. 2024 Aug;632(8025):656-663.
[3] Mravec J, Kračun SK, Zemlyanskaya E, et al. Click chemistry-based tracking reveals putative cell wall-located auxin binding sites in expanding cells. Sci Rep. 2017 Nov 22;7(1):15988.
[4] Dawodu O, White CA, Specht C, et al. Copper-catalysed azide-alkyne cycloaddition on live M13 bacteriophage for expanding the molecular diversity of phage-displayed peptide libraries. RSC Chem Biol. 2025 Aug 14;6(10):1555-1565.
Biotin-PEG4-alkyne是一种结合了生物素、四聚乙二醇（PEG4）和末端炔基的功能化化合物。Biotin-PEG4-alkyne可通过点击化学反应与叠氮基团高效偶联形成稳定的三唑键，通过PEG4链增强水溶性和生物相容性以减少非特异性结合和空间位阻。Biotin-PEG4-alkyne可用于生物标记、药物递送系统和PROTAC分子构建的相关研究[1-4]。