Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].
PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].