Biotin-COG1410 TFA is a biotin labled COG1410 (neurological disease[1][2].
Cog1410 (1-25 μm; 48 h) 降低 BV2 小胶质细胞 NO 和 TNFα 的产生和释放[1]。
COG1410 (0.3-0.6 mg/kg；单次静脉注射) 对小鼠前庭运动功能的短期测试和空间学习和记忆的长期测试有显著改善[1]。
COG1410 (0.8 mg/kg；单次静脉注射) 可改善大鼠前庭运动功能，减少脑卒中后运动不对称性，并减少同侧半球梗死体积[2]。
[1]. Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107.
[2]. Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82.
[3]. Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980.