GlpBio

Bidisomide (SC40230)

目录号: GC34050纯度: >99.50%同义词: 比地索胺; SC40230
Bidisomide (SC40230) (SC40230) 是一种 I 类抗心律失常药物。
Bidisomide (SC40230)
Cas No.: 116078-65-0
规格价格库存数量操作
1mg¥1,294.00现货
1
5mg¥3,207.00现货
1
10mg¥4,467.00现货
1
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产品描述 Description

Bidisomide (SC40230) is a class I antiarrhythmic agent.

The antiarrhythmic effects of Bidisomide, a new class I antiarrhythmic drug is investigated in early-phase ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Bidisomide (5 mg/kg) reduces the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to Mexiletine (MXT) and Disopyramide (DSP) in rats with ventricular arrhythmias induced by coronary artery occlusion. In rats with ventricular arrhythmias induced by coronary artery reperfusion following a 5 min coronary occlusion, the antiarrhythmic effects of 5 mg/kg of Bidisomide are similar to those of the same doses of MXT and DSP. All three drugs significantly slow the heart rate[1].

[1]. Komori S, et al. Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessels. 1995;10(1):7-11.

实验参考方法 Experimental Reference Method

Animal experiment:

Rats[1]Male Sprague-Dawley rats weighing 200-280g are used. Thirty-nine rats receive intravenous infusion of saline (n=9), Bidisomide (5 mg/kg, n=10), Mexiletine (MXT, 5 mg/kg, n=10), or Disopyramide (DSP, 5 mg/kg, n=10). In preliminary experiments, 5 mg/kg of MXT and DSP have significant antiarrhythmic effects. The same dose of Bidisomide is used. The injection volume of each agent is adjusted to 0.5 mL with saline. Coronary artery occlusion is induced 5min after drug administration. Electrocardiograms and systemic arterial blood pressure are recorded for 30 min after induction of coronary artery occlusion.

References:

[1]. Komori S, et al. Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessels. 1995;10(1):7-11.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
116078-65-0
同义词
比地索胺; SC40230
SMILES
CC(C)N(C(C)=O)CCC(C(N)=O)(C1=C(C=CC=C1)Cl)CCN2CCCCC2
分子式
C22H34ClN3O2
分子量
407.98 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol