Betaxolol-d7 (hydrochloride)

Betaxolol-d₇ is intended for use as an internal standard for the quantification of betaxolol by GC- or LC-MS. Betaxolol is an antagonist of the β₁-adrenergic receptor (β₁-AR; K_i = 23 nM).¹ It is selective for the β₁-AR over the β₂-AR (K_i = 790 nM). Betaxolol is cytotoxic to 10.014 pRSV-T human corneal epithelial cells.² It reduces intraocular pressure in cynomolgus monkeys with ocular pertension induced by laser trabeculoplasty when administered at a dose of 150 µg/animal.³ Betaxolol also inhibits sodium influx induced by the neurotoxin veratridine in rat cortical synaptosomes (IC₅₀ = 28.3 µM).⁴