β-CGRP, human is a neuropeptide hormone produced by the calcitonin gene-related peptide family, which forms a complex with calcitonin receptor-like receptors CRLR and RAMP (CRLR/RAMP1: IC50 =1nM; CRLR/RAMP2: IC50 = 300nM) [1]. β-CGRP, human activates the adenylate cyclase-cAMP-PKA signaling pathway by binding to the CGRP receptor complex (composed of CALCRL and RAMP1), inducing physiological effects such as vascular smooth muscle relaxation, neuronal excitation regulation, and inflammation mediation [2-3]. β-CGRP, human is mainly used in research on migraine, cardiovascular regulation, neuroinflammation, and pain [4].
In A549 cells, β-CGRP, human (0.1-10nM; 24h) markedly increases heart rate in rats, and reduces IL-1β-induced production of IL-8 and MCP-1 [5]. In endothelial cells, β-CGRP, human (1-30μM; 24h) induces concentration-dependent relaxation of pre-contracted human intracranial arterial ring segments [6].
References:
[1]. McLatchie L M, Fraser N J, Main M J, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor[J]. Nature, 1998, 393(6683): 333-339.
[2]. Bonura A, Brunelli N, Marcosano M, et al. Calcitonin gene-related peptide systemic effects: embracing the complexity of its biological roles—a narrative review[J]. International Journal of Molecular Sciences, 2023, 24(18): 13979.
[3]. Tsukiji J, Sango K, Udaka N, et al. Long-term induction of β-CGRP mRNA in rat lungs by allergic inflammation[J]. Life sciences, 2004, 76(2): 163-177.
[4]. Shen Y T, Pittman T J, Buie P S, et al. Functional role of α-calcitonin gene-related peptide in the regulation of the cardiovascular system[J]. The Journal of Pharmacology and Experimental Therapeutics, 2001, 298(2): 551-558. [1].
[5]. Li W, Hou L, Hua Z, et al. Interleukin‐1β induces β‐calcitonin gene‐related peptide secretion in human type II alveolar epithelial cells[J]. The FASEB journal, 2004, 18(13): 1603-1605.
[6]. Jansen-Olesen I, Jørgensen L, Engel U, et al. In-depth characterization of CGRP receptors in human intracranial arteries[J]. European journal of pharmacology, 2003, 481(2-3): 207-216.
β-CGRP, human是一种神经肽激素，由降钙素基因相关肽家族产生，可与降钙素受体样受体CRLR和RAMP形成复合物（CRLR/RAMP1：IC50 = 1nM；CRLR/RAMP2：IC50 = 300nM） [1]。β-CGRP, human通过与CGRP受体复合物（由CALCRL和RAMP1组成）结合，激活腺苷酸环化酶-cAMP-PKA信号通路，从而诱导血管平滑肌舒张、神经元兴奋调节和炎症介导等生理效应 [2-3]。β-CGRP, human主要用于偏头痛、心血管调节、神经炎症和疼痛的研究 [4]。
在A549细胞中，β-CGRP, human（0.1-10nM；24h）可显著增加大鼠的心率，并降低IL-1β诱导的IL-8和MCP-1的产生 [5]。在内皮细胞中，β-CGRP, human（1-30μM；24h）可诱导预收缩的人颅内动脉环段浓度依赖性舒张 [6]。