Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits[1][2].
Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents[1].
Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits[2].
[1]. Mori M, et al. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80.
[2]. Nakamura H, et al. AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits. J Pharm Pharmacol. 1984 Mar;36(3):182-6.