Bax Inhibitor Peptide V5 (trifluoroacetate salt)

Bax inhibitor peptide V5 is an inhibitor of Bax.¹ It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-?B p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 µM.² It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 µM.¹ Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.³ Bax inhibitor peptide V5, when used at a concentration of 100 µM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin .²

1.Yoshida, T., Tomioka, I., Nagahara, T., et al.Bax-inhibiting peptide derived from mouse and rat Ku70Biochem. Biophys. Res. Commun.321(4)961-966(2004) 2.Rivas-Carrillo, J.D., Soto-Gutierrez, A., Navarro-Alvarez, N., et al.Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in miceDiabetes56(5)1259-1267(2007) 3.Wang, X., Han, W., Du, X., et al.Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injuryStroke41(9)2050-2055(2010)