BAmP-O16B is an ionizable cationic amino lipid that has been used in the generation of lipid nanoparticles (LNPs).[1] LNPs containing BAmP-O16B and encapsulating NSA-inactivated RNase A reduce the viability of SiHa and HeLa cancer cells, but not non-cancerous NIH3T3 and HEK293T cells, upon intracellular reactivation of RNase A by glutathione (GSH).
References:
[1].Zheng, Q., Ma, T., and Wang, M.Unleashing the power of proenzyme delivery for targeted therapeutic applications using biodegradable lipid nanoparticlesAcc. Chem. Res.57(2)208-221(2024).