Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin > R837 [1].
References:
[1]. Takouda J, et al. Identification of Azalamellarin N as a Pyroptosis Inhibitor. Biol Pharm Bull. 2024;47(1):28-36.