ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse.
ATF3 inducer 1 (compound 16c) (50 μM; 8 days) increases the ATF3 protein and ATF3 mRNA expression in 3T3-L1 cells[1].
ATF3 inducer 1 (40 mg/kg; i.p.; three times a week for 10-weeks) shows anti-MetS (managing metabolic syndrome) activity in mouse[1].
References:
[1]. Chang YH, et al. Exploration and biological evaluation of 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one as an activating transcription factor 3 inducer for managing metabolic syndrome. Eur J Med Chem. 2022 Nov 25;246:114951.