ASR-488 activates the mRNA-binding protein CPEB1, induces Showed that the IC 50 of TCCSUP was 800, 480 and 450 nM at different time periods of 24, 48 and 72 hours, and the IC 50 of HT1376 was 1.28 µM, 750 and 850 nM, respectively.
Caused a downregulation of p65 and Bcl-2 expression and a marked increase in apoptosis in TCCSUP and HT1376 cells.
[1]. Ashish Tyagi, et al. ASR488, a novel small molecule, activates an mRNA binding protein, CPEB1, and inhibits the growth of bladder cancer. Oncol Lett. 2020 Jul;20(1):850-860.