Aromadendrene is a sesquiterpene that has been found in E. globulus and has diverse biological activities.1,2,3 It is active against various strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE; MICs = 0.25-1 mg/ml).1 Aromadendrene (1 mM) inhibits tert-butyl hydroperoxide-induced formation of thiobarbituric acid reactive substances (TBARS) in isolated rat liver hepatocytes.2 It inhibits the proliferation of HepG2 liver and PC3 prostate cancer cells (IC50s = 20 and 9.3 µM, respectively).3
1.Mulyaningsih, S., Sporer, F., Reichling, J., et al.Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogensPharm. Biol.49(9)893-899(2011) 2.Vinholes, J., Rudnitskaya, A., GonÇalves, P., et al.Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approachFood Chem.14678-84(2014) 3.Al-Lihaibi, S.S., Alarif, W.M., Abdel-Lateff, A., et al.Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: isolation and antiproliferative activity against HepG2 cellsEur. J. Med. Chem.81314-322(2014)