Argireline (Acetyl hexapeptide-3) is a synthetic peptide that is patterned from the N-terminal end of the protein SNAP-25 [1]. Argireline inhibits vesicle docking by preventing formation of the ternary SNARE complex and by interfering in catecholamine release [2]. Argireline is used in cosmetic formulations to reduce facial muscle contractions, thus preventing the formation of expressive wrinkles, mainly on the forehead and around eyes[3].
In vitro, Argireline treatment for 48 hours significantly inhibited the viability of HEK-293 cells and IMR-32 cells, with IC50 values of 34.862μM and 68.458μM, respectively[4].
References:
[1] Dana A, Rotsztejn H. The peptide argireline-the importance of local application on the skin, in the light of current knowledge[J]. Letters in Drug Design & Discovery, 2017, 14(10): 1215-1220.
[2] Wang Y, Wang M, Xiao S, et al. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study[J]. American journal of clinical dermatology, 2013, 14(2): 147-153.
[3] Blanes‐Mira C, Clemente J, Jodas G, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity[J]. International journal of cosmetic science, 2002, 24(5): 303-310.
[4] Grosicki M, Latacz G, Szopa A, et al. The study of cellular cytotoxicity of argireline-an anti-aging peptide[J]. Acta Biochimica Polonica, 2014, 61(1).
Argireline (Acetyl hexapeptide-3)是一种合成肽，结构模式来源于蛋白SNAP-25的N末端[1]。Argireline通过阻止三元SNARE 复合物的形成并干扰儿茶酚胺的释放来抑制囊泡锚定[2]。Argireline用于化妆品配方中，以减少面部肌肉收缩，从而预防表情纹的产生，尤其是在前额和眼周区域[3]。
在体外，Argireline处理HEK-293细胞和IMR-32细胞48小时，显著抑制了细胞活力，IC50值分别为 34.862μM和68.458μM[4]。